in order to evaluate the effect of berberis vulgaris extract on the experimental ulcers of cutaneous leishmaniasis (cl) on balb/c mice, a study was undertaken over a 12 months period. forty balb/c mice were divided into 2 main groups a and b. each main group in turn was divided into 5 sub groups of 4 mice and each sub group were inoculated subcutaneously by 0.1ml liquid phase culture containing...

background and aims: aspergillus fumigatus is a sporadic fungus that causes different infections and allergies in immunocompromised patients. the allergic disease caused by this fungus is called allergic bronchopulmonary aspergillosis (abpa). abpa is considred important in atopic and immunocompromised individuals, which can result in inflammation and epithelial damage. therefore, the aim of thi...

increased arginase activity in the airways decreases l-arginine and causes deficiency of bronchodilating and anti-inflammatory nitric oxide (no) in asthma. as, it is suggested that l-arginine may have therapeutic potential in asthma treatment, we aimed to investigate the effects of inhaled l-arginine on oxygen saturation (sao₂) and airway histology in a murine model of acute asthma. twenty eigh...

how to cite this article: wilson md. animal models of cerebral palsy: hypoxic brain injury in the newborn. iran j child neurol. spring 2015; 9(2):9-16. abstract objective hypoxic insults are implicated in the spectrum of fetal disorders, including cerebral palsy (cp). in view of the major contribution of intrapartum risk factors and prematurity to subsequent neurological morbidity and mortality...

background: toxoplasma gondii , an apicomplexan parasite, is capable of infecting a broad range of intermediate warm-blooded hosts including humans. the parasite seems to be capable of altering the natural behavior of the host to favor its trans-mission in the environment. the aim of this study was to evaluate the course, alter-ations in behavior along with normal kinetics of the abnormally ind...

conclusions the development of delivery systems into bacteria with an efficacy compatible to that in human use could be a key for the potential utility of sirna for the prophylaxis and treatment of p. aeruginosa-induced hematogenous pulmonary infections in humans. results in quantitative rt–pcr,it was shown that the sirna significantly inhibited the expression of the flagella mrna. filc gene kn...

garlic is known as a potent spice and a medicinal herb with broad therapeutic properties ranging from antibacterial to anticancer and anticoagulant. our previous studies have shown some immunoregulatory effects for aged garlic extract, suggesting a key role for 14-kd glycoprotein of garlic in shifting the cytokine pattern to t helper-1. in present study, we investigated the effect of 1, 2, and ...

allergic asthma is a complex and chronic inflammatory airway disease. interleukin-17 is a pro-inflammatory cytokine which plays critical role in the pathogenesis of allergic asthma. it has been reported that β-arrestin2 regulated the development of allergic asthma at a proximal step in the inflammatory cascade. in this study, the influence of β-arrestin2 on interleukin-17 production and express...

Research on new compounds of therapeutic value for behavioral disorders has progressed recently. Several studies have reported neuropharmacological activities of plant derived terpenes. Farnesol is a sesquiterpene whose most popular source is fruits but the anxiolytic activity for farnesol is still unknown. The present study was conducted on 32 male Swiss Albino mice (8 in each group) to evalua...